Current Issue : January-March Volume : 2014 Issue Number : 1 Articles : 2 Articles
The present study was undertaken to determine the antiulcer activity of the ethanol extract from the leaves of Pistia stratiotes. The preliminary phytochemical investigation showed the presence of alkaloids, flavonoids, terpenoids, tannins, cardiac glycosides, gums and phytosteroids. The pharmacological and acute toxicity studies of ethanol extract was performed according to OECD-423 guidelines (Acute toxic class method). No mortality or toxicity was observed (3 days) up to 2000mg/kg of body weight. Flavonoids, tannins and triterpenes are among the cytoprotective active materials for which antiulcerogenic efficacy has been extensively confirmed. It is suggested that these compounds will be able to stimulate mucus, bicarbonate and prostaglandin secretion, and counteract with the deteriorating effects of reactive oxidants in gastrointestinal lumen. Tannins may prevent ulcer development due to their protein precipitating and vasoconstriction effects. Their astringent action can help precipitating micro proteins on the ulcer site, thereby forming an impervious layer over the lining that hinders gut secretions and protects the underlying mucosa from toxins and other irritants....
Parkinson disease is progressive neurodegenerative disease occurs due to several causative factor although dopamine deficiency is prime characteristic of the disease. Environmental toxin, genetic abnormalities, drugs, oxidative stress are some of causative factor responsible development of parkinson disease. Currently available drugs for the treatment of this disorder are able to provide only symptomatic relief. Moreover their use is associated with lot of adverse effects. The importance of medicinal plants comes in this context. In present study haloperidol was used to induce the Parkinsons like symptoms in wistar albino rats. Hydro-alcoholic extracts of Parkinsonia aculeate L. seeds at the dose (200mg/kg) was administered orally. After one hour haloperidol (1 mg/kg p.o.) was administered. Catalepsy score was recorded at interval of one hour. The results indicate that administration of haloperidol significantly induced the catalepsy in wistar albino rats, which was significantly reversed by administration of hydroalcoholic extract of Parkinsonia aculeata L. Seeds. (P<0.05) and Ananas cosmosus L....
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